Pueraria mirifica is Thailand’s endemic species found mainly in the northern and western part of Thailand and has local name as “White Kwao Krua” or “Red Kwao Krua” or “Kwao Krua”. The Thai vine herbal plant is grown in association with the moderate-size trees ranking from timber wood to bamboo in the deciduous rain forest. The enlarge underground tuber accumulate “phytoestrogens” comprising isoflavone. The compounds that make Pueraria mirifica different from any other phytoestrogen- containing plants in the Family Leguminosae are Miroestrol and Deoxymiroestrol, which possess highest estrogenic activity among the known phytoestrogens due to structural similarity to estradiol.
Miroestrol was actually the first compound isolated from this plant by a group of German chemists in 1940, but the plant had been mistakenly reported then as Butea superba. It was later on classified as a new plant called Pueraria mirifica Airy Shaw et Suvatabhandu. The isolation and identification of deoxymiroestrol from the root of Pueraria mirifica has just been reported in the February 2000 issue of the Journal of Natural Products. The authors proposed that since deoxymiroestrol is easily oxidized to miroestrol, deoxymiroestrol, not the previously reported miroestrol, is more likely to be the actual chemical constituent of Pueraria mirifica. However, it is very likely that the two phytoestrogens coexist in the root of this plant. AS shown below, the chemical structures of the two compounds are very similar to that of estradiol, the main human estrogen.
In addition to miroestrol and deoxymiroestrol, Pueraria mirifica also contains other chemicals that belong to isoflavone and coumestran groups of phytoestrogens, e.g., Genistein, Daidzein, Daidzin, Genistin, and Coumestrol that are usually found in soybeans. (Table). However, the estrogenic activity of Miroestrol and Deoxymiroestrol is much more potent than that of soy isoflavones.
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Friday, August 22, 2008
“Kwao Krua” inThailand is Pueraria mirifica
Pueraria Mirifica Builds Up For Breast Produces Hormone In Menopause
Pueraria Mirifica Builds Up For Breast Produces Hormone In Menopause
A committee is appointed to study Pueraria mirifica. It is reportedly found to be efficient in building up the breast and working as a substitute hormone in Menopause women. The government sector is ready to revise the law for Pueraria mirifica to be a dietary reinforcement product. The result is expected to be known in 3 months.
Dr. Suraphong Suepwongli, the Deputy Minister of Public Health, has said that a meeting of the working group considering Pueraria mirifica, which consister of a group of researchers from Chulalongkorn University, the National Cancer Institute, the Institute of Dermatology, the Department of Medical Sciences, Mae Fa Luang University, etc., was held to determine whether or not it would be possible to promote Pueraria mirifica production as a topping industry for commercialized distribution, as a conclusion of which a national-level committee was set up to be in charge of pushing Pueraria mirifica, with Mrs. Khrueawan Somana, the Advisor to the Deputy Minister of Public Health, acting as the chairman of the working group for revising the law, since it lags far behind the laws of other countries. The meeting also arrived at a conclusion that Pueraria mirifica is clinically efficient in working as a substitute in menopause women and there is a trend that it will be used to build up the breast and to cure Alzheimer’s disease by generating a regrowth of cells.
As regards toxicity, there is a conclusion from the National Cancer Institute that Pueraria mirifica is non-carcinogenic and this conforms to a research finding of King Mongkut’s Hospital that Pueraria mirifica can also prevent cancer, so there came a conclusion that a national-level committee be set up to be in charge of pushing Pueraria mirifica, which will consider from research at a clinical and the revision of the medicinal herb law, because there is not yet any favoring law, and this law lags for behind the laws of other countries.
So far, we've uncovered some interesting facts about Pueraria mirifica. You may decide that the following information is even more interesting.
The patent question was extensively discussed, Dr. Suraphong said, because there is already a case of patent registration by a Thai. In fact, that is a patent registration seeking to concoct Pueraria mirifica as an ancient intellectual background. The focus at this moment is a process of turning the effective substance in Pueraria mirifica into a standard product and taking the process to register a patent, which a representative of the Department of Intellectual Property will be invited to joint in considering, and where possible, the patent will also be registered aboard.
Dr. Suraphong quoted Prof. Dr. Urusa Thepphisai, a researcher from Ramathibodi Hospital, as saying that Pueraria mirifica is registered as a traditional drug under the Drug Act, while in the United States of America Europe and Japan it is dietary reinforcement product. The Department of Medical Sciences, the Food and Drug Administration and the Institute of Thai Traditional Medicine have been ordered to collect group of ideas to revise the law within 3 months for the Cabinet to consider subsequently.
Pueraplus is a premuim grade Thai traditional herbal formula derived mainly from White Kwao Krua (Pueraria Mirifica) which contains Phytoestrogens (Natural Plant Estrogen). After many years of research from Thailand, the studies indicated that this herb shows estrogenic and rejuvenate effects to the female body especially at the breast, hip, facial skin, body skin, hair and vaginal epithelium. Thus elevate the appearance of the female secondary sexual characteristics and also the skin beauty.
Thank natural to make herbals for good life!
